Total syntheses of arylindolizidine alkaloids (+)-ipalbidine and (+)-antofine.
نویسندگان
چکیده
This paper presents the first application of two recently developed reactions to natural product synthesis. The first method involves a 6-endo-trig cyclization to prepare a versatile chiral enaminone building block. The second is a direct C-H arylation reaction. As a showcase for the utility of these methods, (+)-antofine and (+)-ipalbidine were synthesized in only 8 steps and 24-26% overall yields.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 75 17 شماره
صفحات -
تاریخ انتشار 2010